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Pain Relief:

TRAMADOL - PAIN RELIEF MEDICATION

Tramadol is a pain medication that is similar to ultracet but doesn't have acetaminophen in it,

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. Tramadol is used to treat patients with severe and chronic pain situations. Tramadol is a trade name used for Ultram. Make sure that you don't get Ultram (tramadol) mixed up with Ultracet,

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Tramadol works very fast and is very effective in the matter of a couple of hours,

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. Use tramadol to stop the nerves from sending pain messages to the brain. Tramadol has been around for a few years now, and has taken off in the medical field in the last couple of years,

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. Tramadol is a prescription only medication. When using tramadol, get a doctor to schedule regular checkups to get full satisfaction of using tramadol for treating your pain. For stronger pain medication, a doctor may recommend the use of ultracet.

TRAMADOL IS FDA APPROVED

ortho-McNeil has sent a Dear Doctor letter alerting prescribers to serious adverse effects and abuse potential of the centrally acting analgesic Ultram (generic name: tramadol),

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. Tramadol was approved for treatment of moderate to moderately severe pain (JAMA, 24 April 1996).

Since Tramadol's approval in March 1995, the FDA has received reports of 83 adverse events in the U.S. involving tramadol seizures or convulsions, some occurring after only one dose of the tramadol drug. In most cases there was a predisposing factor of concomitant medication with antidepressants, such as tricyclics (some generic examples are imipramine, amitriptyline) and selective serotonin uptake inhibitors (some brand name examples are Prozac and Zoloft).

The updated tramadol drug label warns about Tramadol's potential for serious drug interaction with all antidepressant medications, antipsychotics and other drugs known to reduce the seizure threshold. The warning section of the tramadol drug label has also been modified to include new cautions about possible extreme allergic reactions,

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, especially in persons with known adverse reactions to codeine and other opioids,

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. Eleven such reports were received by the FDA.

In addition there have been 115 reports of adverse events described as drug abuse, dependence, withdrawal or intentional overdose of tramadol. New drug labeling warns that Ultram (tramadol),

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, which is not a controlled substance, is not recommended for persons with a history of addiction or opioid dependence. The last new caution added to the tramadol label is that the recommended single and daily dosages of Ultram (tramadol) should not be exceeded in attempts to obtain better pain relief..
This article is for informational purposes only about tramadol and tramadol's effects on potential abusers or misleading label readings on tramadol prescriptions. Use tramadol to treat your pain, but be smart about it and get all the facts of tramadol before you use it.

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Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Tramadol (Ultram, Tramal, others below) is a centrally-acting analgesic, used in treating moderate to moderately severe pain. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux, and fibromyalgia. It was developed by the pharmaceutical company Grьnenthal GmbH in the late 1970s

In May 2009, the United States Food and Drug Administration issued a Warning Letter to Johnson & Johnson, alleging that a promotional website commissioned by the manufacturer had "overstated the efficacy" of the drug, and "minimized the serious risks". The company which produced it, the German pharmaceutical company Grьnenthal GmbH, were the ones alleged to be guilty of "minimizing" the addictive nature and proposed efficacy of the drug,

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, although it showed little abuse liability in preliminary tests. The 2010 Physicians Desk Reference contains several warnings from the manufacturer, which were not present in prior years. The warnings include more compelling language regarding the addictive potential of tramadol, the possibility of difficulty breathing while on the medication, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs, nor to be used to manage long-term opiate addiction.

Side Effects of Tramadol - for the ConsumerTramadol/Acetaminophen

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol/Acetaminophen:

Constipation; diarrhea; dizziness; drowsiness; increased sweating; loss of appetite; nausea.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol/Acetaminophen:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest;

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; swelling of the mouth, face, lips, or tongue); severe seizures (convulsions).

Tramadol

All medicines may cause side effects, but many people have no, or minor,

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, side effects,

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. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol:

Constipation;

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; diarrhea; dizziness; drowsiness; dry mouth; headache; nausea; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol:

Severe allergic reactions (rash;

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; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation;

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;
chest pain; difficult or painful urination; disorientation; fainting; hallucinations; irregular heartbeat; loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen,

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,
or peeling skin; seizures; severe dizziness or lightheadedness.

Tramadol Extended-Release Tablets

All medicines may cause side effects, but many people have no,

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, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol Extended-Release Tablets:

Constipation; diarrhea; dizziness; drowsiness; dry mouth;

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; headache; increased sweating; nausea; trouble sleeping; vomiting;

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;
weakness.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol Extended-Release Tablets: phentermine with out a doctor,

Severe allergic reactions (rash;

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; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips,

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,
or tongue; unusual hoarseness); agitation; chest pain; difficult or painful urination; disorientation; fainting; hallucinations; irregular heartbeat;

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;
loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen,

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,
or peeling skin; seizures; severe dizziness or lightheadedness.

Side Effects by Body SystemGastrointestinal

Gastrointestinal side effects are common. Nausea and constipation occur within the first 90 days of therapy in 40% and 46% of treated patients,

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, respectively. Vomiting, diarrhea, dyspepsia, anorexia, flatulence, abdominal pain, and dry mouth have also been reported.

Nervous system

Seizures have been reported in patients receiving the normal recommended dose. The risk for seizures is increased with doses above the recommended range.

Nervous system side effects occur frequently. Dizziness,

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, headache, and somnolence have been reported in more than 25% of treated patients during the first three months of therapy. CNS stimulation, including nervousness, anxiety, tremor,

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,
agitation,

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,
euphoria, emotional lability and hallucinations,

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,
has also been reported. Confusion, sleep disorders,

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,
and coordination disturbances have been reported in less than 5% of patients. Seizures have been reported in over 200 cases,

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. Cases of long-lasting delirium have been reported in two elderly patients. A case of serotonin syndrome triggered by tramadol has also been reported.

Dermatologic

Dermatologic side effects including pruritus (11%) have been reported. Rash and urticaria have occurred rarely.

Genitourinary

Genitourinary side effects including urinary retention and urinary frequency have been reported in less than 5% of treated patients.

Cardiovascular

Cardiovascular side effects including tachycardia and orthostatic hypotension have been reported rarely.

Hypersensitivity

The use of tramadol is contraindicated for patients with a history of allergy to any opioid.

Hypersensitivity side effects including anaphylactoid reactions have been reported after first doses of tramadol as well as in patients with a documented history of codeine allergy. Angioedema has been reported rarely.

Other

Other side effects including withdrawal symptoms and, rarely,

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, auditory hallucinations have been reported,

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. A case of vocal cord closure has also been reported.

Metabolic

Metabolic side effects including hyponatremia have been reported.

The maximum dosage for tramadol in any form is 400 mg per day,

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. Certain manufacturers or formulations have lower maximum doses,

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. For example, Ultracet (37.5 mg/325 mg tramadol/APAP tablets) is capped at 8 tablets per day (300 mg/day). Ultram ER is available in 100, 200,

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,
and 300 mg/day doses and is explicitly capped at 300 mg/day as well. Patients taking SSRIs (Prozac, Zoloft, etc.), SNRIs (Efexor, etc.),

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,
TCAs, MAOIs, or other strong opioids (oxycodone,

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,
methadone,

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,
fentanyl, morphine), as well as the elderly (> 75 years old), pediatric (< 18 years old), and those with severely reduced renal (kidney) or hepatic (liver) function should consult their doctor regarding adjusted dosing or whether to use Tramadol at all.

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