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Tapentadol is a drug for pain. It was approved by the US FDA for the treatment of moderate to severe pain. The FDA news release was dated 24 November 2008, headache hydrocodone rebound, although the actual approval was a few days earlier.
Tapentadol acts on μ-opioid receptors, making it similar to morphine and its ilk. Do we need another opioid agonist? And if so, why? Suspicions deepen because it was produced by the same company that makes tramadol. Indeed, , it is similar to tramadol in many ways, headache hydrocodone rebound. Tramadol is the active ingredient in Ultram®, now available as a generic, headache hydrocodone rebound. This is sounding like a familiar me-too drug story.
On the other hand, chronic pain is a common problem:
Chronic pain prevalence estimates were 10.1% for back pain, , 7.1% for pain in the legs/feet, 4.1% for pain in the arms/hands, , and 3.5% for headache. Chronic regional and widespread pain were reported by 11.0% and 3.6% of respondents, respectively.
Existing treatments often are not satisfactory. With opioid medications, there is risk of psychological dependence and various kinds of diversion and misuse. People put it in their noses and veins and things like that. Perhaps more importantly, though, is the fact that some people develop adverse effects at the doses required to achieve adequate pain control, headache hydrocodone rebound.
So what makes tapentadol different?
Much of the information presented here comes from this article:
(-)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): tylenol 3 and tramadol, a Novel µ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties
First, let's look at tramadol, tramadol hcl 50 mg overdose. Tramadol is an agonist for μ-opioid receptors, headache hydrocodone rebound, but it also inhibits reuptake of serotonin and norepinephrine (monoamines). It appears that the effect on monoamines is something that is important for the analgesic effect of tramadol. After all, tramadol is a rather weak agonist of opioid receptors.
Tramadol, , however, has several problems. The weakness of its effect on opioid receptors means that it would not be expected to have a robust effect on acute pain, headache hydrocodone rebound. The fact that tramadol depends upon the monoamine effect for its action, , means that it often works better for chronic pain. (Note that the use of weasel words, e.g, headache hydrocodone rebound. "expected," "often" is intentional; it reflects the fact that different people respond differently.)
Furthermore, tramadol by itself is not very effective unless some of it is metabolized to O-desmethyl-tramadol. This requires an enzyme, headache hydrocodone rebound, cytochrome P450 2D6 (CYP2D6), tylenol 3 and tramadol. Persons who are relatively deficient in CYP2D6 activity, or who are also taking a drug that blocks CYP2D6, may not get the full effect.
Lastly, tramadol is a racemic mixture; that is, it comes in left- and right-handed versions. The actions of the two versions are different, and the actions of the two versions of the metabolite are different. This is not necessarily a problem, but it is a complicating factor.
With the understand on tramadol, we now can take a look at tapentadol to see if it offers any meaningful advantage.
The key differences are: tapentadol has a stronger effect on the reuptake of norepinephrine than serotonin, it does not depend on CYP2D6 activity, and it is not a racemic mixture. All of these factors are advantageous, at least theoretically. Based upon these findings, one would expect that tapentadol would be less prone to cause adverse effects, and that it would be much less likely to be involved in drug interactions. Premarketing data are encouraging, though.
Additionally, tapentadol is more potent than tramadol at the μ-opioid receptor, but less potent than morphine. Note, , however, that higher potency does not necessarily translate into higher clinical utility.
I tend to think that the advantages are great enough to justify the development of tapentadol for the market. There are so caveats, however. It is not possible to make any firm assessment of a risks of a drug, headache hydrocodone rebound, prior to its release into the wider market. That is, the basic pharmacology suggests that most patients will be less likely to have adverse effects, but this remains to be seen.
Also, , as is the case with any opioid agonist, the potential for diversion and abuse cannot be assessed fully. There are examples of drugs that were thought to present a minimal risk of abuse, headache hydrocodone rebound, prior to being released into the wild, but for which that turned out not to be the case, headache hydrocodone rebound. Talwin, , Stadol, and of course Oxycontin, come to mind in this respect. Iwould be very cautious about making any assumptions about the potential for diversion and abuse with tapentadol. In fact, the DEA has yet to assign the drug into one of its schedules.
As for what I think of tapentadol, , I suspect that it will turn out to be useful, headache hydrocodone rebound, but not a blockbuster. If the safety profile is significantly better than that for tramadol, headache hydrocodone rebound, it may be possible to use it at higher doses, which might translate into greater clinical utility, headache hydrocodone rebound.
I do have two big questions, though, headache hydrocodone rebound. One: corner pharmacy tramadol, is this drug really any better than a combination of a medium-strength opioid, say hydrocodone, along with a norepinephrine reuptake inhibitor, say nortriptyline? Both are pretty inexpensive, , so for the tapentadol to have a rational place in our pharmacopoeia, it would have to have some benefit that cannot be gotten for less money. (Not that markets are always rational, but still...)
Two: tramadol hcl 50 mg overdose, what it is potential for lowering the seizure threshold? Tramadol does this. It usually is not an issue unless a person takes a great deal more than what was prescribed, or it there is a drug interaction. The drug interaction should not be a problem with tapentadol, but we can assume that many persons will take doses that are larger than prescribed. Tapentadol presumably will come with a warning about that, , but that won't stop many people, headache hydrocodone rebound. Note that I do not consider this a reason to keep the drug off the market, , but I do think that clinicians should keep the possibility in mind.
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Disclosure: headache hydrocodone rebound, I don't own any pharmaceutical stocks (not directly, , anyway; I probably have some small bit in a mutual fund somewhere), nor do I work for any company that has anything to do with any of the products mentioned, headache hydrocodone rebound.
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