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Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock. Tramadol (Ultram, saturday delivery cod tramadol, Tramal, others below) is a centrally-acting analgesic, used in treating moderate to moderately severe pain, tramadol hcl tab 50mg side effects. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux, and fibromyalgia, tramadol hcl tab 50mg side effects. It was developed by the pharmaceutical company Grьnenthal GmbH in the late 1970s In May 2009, the United States Food and Drug Administration issued a Warning Letter to Johnson & Johnson, alleging that a promotional website commissioned by the manufacturer had "overstated the efficacy" of the drug, and "minimized the serious risks", tramadol hcl tab 50mg side effects. The company which produced it, the German pharmaceutical company Grьnenthal GmbH, were the ones alleged to be guilty of "minimizing" the addictive nature and proposed efficacy of the drug, although it showed little abuse liability in preliminary tests. The 2010 Physicians Desk Reference contains several warnings from the manufacturer, which were not present in prior years. The warnings include more compelling language regarding the addictive potential of tramadol, liver damage from tramadol, the possibility of difficulty breathing while on the medication, tramadol hcl tab 50mg side effects, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts, tramadol hcl tab 50mg side effects. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs, nor to be used to manage long-term opiate addiction. Side Effects of Tramadol - for the ConsumerTramadol/Acetaminophen All medicines may cause side effects, tramadol hcl tab 50mg side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol/Acetaminophen: Constipation; diarrhea; ; dizziness; drowsiness; increased sweating; loss of appetite; ; nausea. Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol/Acetaminophen: Severe allergic reactions (rash; hives; tramadol hcl tab 50mg side effects; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, saturday delivery cod tramadol, lips, or tongue); severe seizures (convulsions). Tramadol All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol: Constipation; diarrhea; ; dizziness; drowsiness; ; dry mouth; headache; nausea; trouble sleeping; vomiting; weakness. Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol: Severe allergic reactions (rash; hives; ; itching; difficulty breathing; tightness in the chest; swelling of the mouth, tramadol all about, face, lips, or tongue); agitation; ; chest pain; tramadol hcl tab 50mg side effects; difficult or painful urination; disorientation; tramadol hcl tab 50mg side effects; fainting; hallucinations; irregular heartbeat; ; loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen, or peeling skin; seizures; ; severe dizziness or lightheadedness. Tramadol Extended-Release Tablets All medicines may cause side effects, tramadol hcl tab 50mg side effects, but many people have no, tramadol all about, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol Extended-Release Tablets: Constipation; diarrhea; dizziness; drowsiness; ; dry mouth; headache; increased sweating; nausea; trouble sleeping; vomiting; weakness. Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol Extended-Release Tablets: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, tramadol all about, lips, or tongue; unusual hoarseness); agitation; chest pain; tramadol hcl tab 50mg side effects; difficult or painful urination; disorientation; fainting; hallucinations; irregular heartbeat; loss of coordination; mood or mental changes (eg, depression); tramadol hcl tab 50mg side effects; red, blistered, swollen, or peeling skin; seizures; severe dizziness or lightheadedness. Side Effects by Body SystemGastrointestinalGastrointestinal side effects are common, tramadol hcl tab 50mg side effects. Nausea and constipation occur within the first 90 days of therapy in 40% and 46% of treated patients, respectively. Vomiting, diarrhea, dyspepsia, anorexia, flatulence, liver damage from tramadol, abdominal pain, and dry mouth have also been reported. Nervous systemSeizures have been reported in patients receiving the normal recommended dose. The risk for seizures is increased with doses above the recommended range. Nervous system side effects occur frequently. Dizziness, tramadol all about, headache, and somnolence have been reported in more than 25% of treated patients during the first three months of therapy. CNS stimulation, including nervousness, anxiety, tremor, agitation, euphoria, emotional lability and hallucinations, has also been reported. Confusion, sleep disorders, and coordination disturbances have been reported in less than 5% of patients. Seizures have been reported in over 200 cases. Cases of long-lasting delirium have been reported in two elderly patients. A case of serotonin syndrome triggered by tramadol has also been reported. DermatologicDermatologic side effects including pruritus (11%) have been reported. Rash and urticaria have occurred rarely. GenitourinaryGenitourinary side effects including urinary retention and urinary frequency have been reported in less than 5% of treated patients. CardiovascularCardiovascular side effects including tachycardia and orthostatic hypotension have been reported rarely. HypersensitivityThe use of tramadol is contraindicated for patients with a history of allergy to any opioid. Hypersensitivity side effects including anaphylactoid reactions have been reported after first doses of tramadol as well as in patients with a documented history of codeine allergy. Angioedema has been reported rarely. OtherOther side effects including withdrawal symptoms and, rarely, auditory hallucinations have been reported. A case of vocal cord closure has also been reported. MetabolicMetabolic side effects including hyponatremia have been reported. The maximum dosage for tramadol in any form is 400 mg per day. Certain manufacturers or formulations have lower maximum doses. For example, Ultracet (37.5 mg/325 mg tramadol/APAP tablets) is capped at 8 tablets per day (300 mg/day). Ultram ER is available in 100, 200, and 300 mg/day doses and is explicitly capped at 300 mg/day as well. Patients taking SSRIs (Prozac, Zoloft, tramadol hcl tab 50mg side effects, etc.), SNRIs (Efexor, etc.), TCAs, MAOIs, or other strong opioids (oxycodone, methadone, liver damage from tramadol, fentanyl, morphine), as well as the elderly (> 75 years old), tramadol hcl tab 50mg side effects, pediatric (< 18 years old), and those with severely reduced renal (kidney) or hepatic (liver) function should consult their doctor regarding adjusted dosing or whether to use Tramadol at all. 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