(for veterinary information only)

BRAND NAME: ULTRAM

AVAILABLE IN
50 mg
TABLETS

BACKGROUND:

The search for the relief of pain has existed for centuries if not millennia. It has long been known that the opiates are able to produce excellent analgesia as well as feelings of euphoria. Unfortunately, they are also habit forming, cause respiratory depression, sedation, and hallucinations. As science has examined the brain, several types of opiate receptors have been found such that stimulation of different receptors is responsible for the different effects of the opiates. For example, tramadol alprazolam, the “mu” and “delta” receptors account for analgesia (pain relief), all about tramadol nobody, euphoria, addiction, reduction in heart rate, tramadol alprazolam, and respiratory depression. The “kappa” receptors cause dysphoria (unpleasant feelings), constricted pupils, and sedation. The “sigma” receptors account for hallucinations, tramadol dementia. In the laboratory, it is possible to create opiates that stimulate only some receptors and not others. With delicacy it is possible to create a drug that creates analgesia and euphoria without being addictive or sedating. Tramadol represents such a drug.

In veterinary medicine there has been a recent explosion in the development of non-steroidal anti-inflammatory medications for the control of animal pain, particularly pain associated with canine arthritis. These medications act by inhibiting cyclo-oxygenase (abbreviated "COX"), an enzyme that leads to production of assorted inflammatory biochemicals, tramadol alprazolam. Suppressing this enzyme, suppresses the pain as well as the inflammation. Unfortunately, cyclo-oxygenase also helps produce some much needed biochemicals and it becomes tricky to suppress production of inflammatory products while keeping the helpful ones, tramadol alprazolam. Occasionally, a dog will develop a reaction to one of these anti-inflammatory medications or will develop a liver or kidney problem which is incompatible with their use. These dogs still require pain management and for these patients, promethazine hydrocodone, a “mu” agonist like tramadol may be just the ticket.

Tramadol can be used separately or in combination with non-steroidal anti-inflammatory drugs and can also be used in cats (whereas non-steroidal anti-inflammatory drugs have limited use).

HOW THIS MEDICATION IS USED:

SIDE EFFECTS:

Side effects are considered rare but we list the following for completeness:

If a pet develops apparent sedation or bizarre behavior, tramadol alprazolam, the tramadol dose should be reduced.

INTERACTIONS WITH OTHER DRUGS:

The beauty of this pain reliever is that it is compatible with all the COX -inhibiting non-steroidal anti-inflammatory drugs, possibly even synergizing with them. It is also compatible with joint pain nutriceuticals such as glucosamine, all about tramadol nobody, MSM, chondroitin sulfate etc.

Tramadol is NOT compatible with Deprenyl, promethazine hydrocodone. Animals taking deprenyl either to control Cushing’s Syndrome or to control senility may not take any sort of narcotic medication including tramadol, tramadol alprazolam. Similarly, tramadol is not compatible with other psychoactive drugs such as serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors. If you are not sure if your pet is on one of these medications, check with your veterinarian.

Tramadol may not be compatible with SAMe, a liver and joint support nutriceutical. Until further studies are performed, these two treatments should not be used together.

Tramadol can induce sedation when combined with amitraz, promethazine hydrocodone, the active ingredient in the Preventic tick control collar and also in Promeris Canine, a flea and tick control product. Amitraz is also sometimes used in the treatment of demodectic mange.

CONCERNS AND CAUTIONS:

Tramadol is not passed to nursing young and should be an acceptable pain reliever for a lactating mother.

Tramadol can cause seizures in humans and thus should be used cautiously in animals with a history of seizures.

If discontinuing tramadol after long term use, all about tramadol nobody, it is recommended that it be tapered off rather than abruptly discontinued.

Page last updated: 5/2/2011

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