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is allergic to tramadol or to any of the ingredients of the medication
is allergic to other opioid medications (e.g., codeine, , morphine)
is intoxicated with alcohol or other medications that can depress breathing and consciousness - such as hypnotics, tramadol oveght, other opioids (e.g., codeine or morphine), or psychotropic medications (certain medications for mental health conditions)
has severe kidney function impairment
has severe liver function impairment
has taken monoamine oxidase (MAO) inhibitor medications (e.g., , phenelzine, tranylcypromine) within 14 days
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