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As a consequence several additional warnings were added to the Physicians' Desk reference in the 2010 edition. Many of these warnings were not present or mentioned in earlier editions. The warnings include stronger language stating the addictive nature of tramadol, the chance of breathing difficulties when using the medication, a whole list of additional previously unmentioned serious side effects,

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The risk of becoming addicted to tramadol is not considered high unless the consumer has previously shown a tendency of addiction to drugs or alcohol or has been taking regular doses of the drug for a long time. Many users complain that Tramadol is incredibly difficult to stop compared to other pain medication after having been used for a long period. Patients who were using tramadol for common pain relief have complained withdrawal symptoms including muscle contracture if they are taken off the medication too quickly,

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Due to the addictive properties of tramadol legitimate users are strongly advised to avoid sharing their medication with anybody else. But this is especially true for persons with a previous record of drug abuse and addiction.

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Some states in the US and Canada have classified Tramadol as a controlled substance and require prescriptions. Even the military has banned Tramadol from the regular shelves and is enforcing prescriptions in line with the Military Pain Care Act,

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