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Tramadol is a pain medication typically prescribed to patients in moderate to severe pain who will need pain medication for an extended period of time. An opiate agonist, this medicine alters the way the body feels pain. This medicine comes immediate and extended release form, but it's also available in other forms.


Drug Uses
Patients over 17 years of age with chronic pain that is moderate to severe may be prescribed Tramadol. It is used to treat pain resulting from any disorder causing stiff or painful muscles, or neuropathic pain. This medication works best when taken at the first sign of pain, and may not be as effective if you wait until the pain has worsened.



Available Doses
The dose prescribed varies depending on the condition for which this drug is prescribed. The maximum recommended dose of Tramadol is 400 milligrams a day. For patients on dialysis, the maximum recommended dose is 100 milligrams every 12 hours. For patients with liver disease or cirrhosis, the maximum recommended dose is 50 milligrams every 12 hours. Patients over 75 years of age should not take more than 300 milligrams a day.

Precautions and Risks
Inform your doctor of any allergies you have before starting this medicine. You should not take Tramadol if you have severe breathing problems or take medicine that depresses the nervous system such as sedatives,

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urinary problems, brain disorders,

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kidney disease, liver disease, lung disease,

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or intestinal problems. This drug may make you drowsy, so don't drive until you know how it will affect you. Tramadol is not recommended for use in pregnant women and the drug passes into breast milk. For patients who have used this drug for a long time,

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withdrawal may occur upon ending use of this drug, especially if the dose was high,

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rapid breathing, or sweating. This medicine should not be used in patients with a history of drug or alcohol abuse, as this drug is highly addictive.

Side Effects
Common side effects are nausea, vomiting, constipation, dizziness, headache, or drowsiness. Many Tramadol users will never experience any side effects as a result of this medication. Rare but severe side effects include extreme muscle stiffness, severe abdominal pain, vision changes, or seizures. If you experience any of these symptoms,

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, contact your doctor immediately. An allergic reaction to this drug is possible,

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but rare. If you notice a rash, itching or swelling,

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or trouble breathing after taking Tramadol, seek medical attention. A rare but serious condition called serotonin syndrome could result from use of Tramadol. Seek medical attention if you experience mental changes, restlessness, fast heartbeat,

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severe dizziness, severe nausea or vomiting, or muscle twitches.

Drug Interactions
Tramadol should not be taken with MAO inhibitors. Tell your doctor if you're taking medicine to treat nausea or drugs that cause an increase in serotonin, such as St. John's Wort, Lithium, SSRIs, or medications used to treat migraine headaches. Some medications may affect the way this drug is absorbed into your body, so tell your doctor if you're taking medications like antibiotics or drugs used to treat seizures. Drowsiness may be increased if combined with antihistamines, anti-anxiety drugs, sleep medications,

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, or muscle relaxants.

Overdose
Tramadol should be taken only at the dose prescribed by your doctor. Symptoms of overdose are shallow breathing,

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, irregular heartbeat, loss of consciousness, or heart attack. If you experience any of these symptoms, call a poison control center or emergency room immediately.

Disclaimer
This drug information is not intended to cover all uses, instructions, interactions, precautions, or adverse effects of this medication. It is for general informational purposes only and should not replace the advice of a medical doctor,

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. Specific patients and conditions require specific instructions, and this information should be given by the prescribing doctor,

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. We disclaim all responsibility for the accuracy and reliability of this information, and any consequences resulting from the use of this information, including damages or adverse consequences to persons or property. No warranty, either expressed or implied, is made in regards to this information.






Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Tramadol (Ultram, Tramal, others below) is a centrally-acting analgesic, used in treating moderate to moderately severe pain. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux,

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, and fibromyalgia. It was developed by the pharmaceutical company Grьnenthal GmbH in the late 1970s

In May 2009, the United States Food and Drug Administration issued a Warning Letter to Johnson & Johnson, alleging that a promotional website commissioned by the manufacturer had "overstated the efficacy" of the drug, and "minimized the serious risks",

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. The company which produced it, the German pharmaceutical company Grьnenthal GmbH, were the ones alleged to be guilty of "minimizing" the addictive nature and proposed efficacy of the drug, although it showed little abuse liability in preliminary tests. The 2010 Physicians Desk Reference contains several warnings from the manufacturer, which were not present in prior years. The warnings include more compelling language regarding the addictive potential of tramadol, the possibility of difficulty breathing while on the medication, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs,

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nor to be used to manage long-term opiate addiction.

Side Effects of Tramadol - for the ConsumerTramadol/Acetaminophen

All medicines may cause side effects, but many people have no,

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, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol/Acetaminophen:

Constipation; diarrhea; dizziness; drowsiness;

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; increased sweating;

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loss of appetite; nausea.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol/Acetaminophen:

Severe allergic reactions (rash; hives; itching; difficulty breathing;

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; tightness in the chest;

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swelling of the mouth, face, lips, or tongue); severe seizures (convulsions).

Tramadol

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol:

Constipation;

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dizziness; drowsiness;

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dry mouth; headache; nausea; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face,

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, lips, or tongue); agitation; chest pain; difficult or painful urination; disorientation; fainting; hallucinations; irregular heartbeat; loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen,

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or peeling skin; seizures; severe dizziness or lightheadedness.

Tramadol Extended-Release Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol Extended-Release Tablets:

Constipation; diarrhea; dizziness; drowsiness;

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; dry mouth; headache;

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increased sweating; nausea; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol Extended-Release Tablets:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); agitation; chest pain;

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; difficult or painful urination; disorientation; fainting;

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hallucinations; irregular heartbeat; loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen, or peeling skin; seizures; severe dizziness or lightheadedness.

Side Effects by Body SystemGastrointestinal

Gastrointestinal side effects are common. Nausea and constipation occur within the first 90 days of therapy in 40% and 46% of treated patients, respectively. Vomiting, diarrhea, dyspepsia, anorexia, flatulence, abdominal pain,

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, and dry mouth have also been reported.

Nervous system

Seizures have been reported in patients receiving the normal recommended dose. The risk for seizures is increased with doses above the recommended range.

Nervous system side effects occur frequently. Dizziness, headache, and somnolence have been reported in more than 25% of treated patients during the first three months of therapy. CNS stimulation, including nervousness, anxiety,

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emotional lability and hallucinations, has also been reported. Confusion, sleep disorders, and coordination disturbances have been reported in less than 5% of patients. Seizures have been reported in over 200 cases. Cases of long-lasting delirium have been reported in two elderly patients. A case of serotonin syndrome triggered by tramadol has also been reported.

Dermatologic

Dermatologic side effects including pruritus (11%) have been reported. Rash and urticaria have occurred rarely.

Genitourinary

Genitourinary side effects including urinary retention and urinary frequency have been reported in less than 5% of treated patients.

Cardiovascular

Cardiovascular side effects including tachycardia and orthostatic hypotension have been reported rarely.

Hypersensitivity

The use of tramadol is contraindicated for patients with a history of allergy to any opioid.

Hypersensitivity side effects including anaphylactoid reactions have been reported after first doses of tramadol as well as in patients with a documented history of codeine allergy. Angioedema has been reported rarely.

Other

Other side effects including withdrawal symptoms and, rarely, auditory hallucinations have been reported,

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. A case of vocal cord closure has also been reported.

Metabolic

Metabolic side effects including hyponatremia have been reported.

The maximum dosage for tramadol in any form is 400 mg per day,

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. Certain manufacturers or formulations have lower maximum doses. For example, Ultracet (37.5 mg/325 mg tramadol/APAP tablets) is capped at 8 tablets per day (300 mg/day),

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. Ultram ER is available in 100, 200, and 300 mg/day doses and is explicitly capped at 300 mg/day as well,

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. Patients taking SSRIs (Prozac, Zoloft, etc.), SNRIs (Efexor, etc.), TCAs, MAOIs, or other strong opioids (oxycodone, methadone, fentanyl, morphine), as well as the elderly (> 75 years old), pediatric (< 18 years old), and those with severely reduced renal (kidney) or hepatic (liver) function should consult their doctor regarding adjusted dosing or whether to use Tramadol at all.

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